94376-75-7

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94376-75-7 Structure

Identification	Back Directory
[Name] alpha, oMega-Dipropionic acid hexaethylene glycol
[CAS] 94376-75-7
[Synonyms] 94376-75-7 Bis-PEG7-COOH Bis-PEG7-acid Bis-PEG8-acid HOOC-PEG6-COOH COOH-PEG6-COOH COOH-PEG7-COOH Bis(3-PEG6)propionic acid HOOCCH2CH2O-PEG6-CH2CH2COOH α,ω-Dipropionic acid hexaethylene glycol 4,7,10,13,16,19,22-Heptaoxapentacosanedioic acid alpha, oMega-Dipropionic acid hexaethylene glycol 3-(2-{2-[2-(2-{2-[2-(2-Carboxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}-ethoxy)propionic acid
[Molecular Formula] C18H34O11
[MDL Number] MFCD11041125
[MOL File] 94376-75-7.mol
[Molecular Weight] 426.46

Chemical Properties	Back Directory
[form ] Viscous Liquid
[color ] Colorless to light yellow

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302-H315-H319-H335
[Precautionary statements ] P261-P305+P351+P338

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[Description]

Bis-PEG7-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

[Biological Activity]

Bis-PEG7-acid is a PROTAC linker belonging to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).

[target]

PEGs

Cleavable

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