| Identification | Back Directory | [Name]
Gadobutrol | [CAS]
138071-82-6 | [Synonyms]
CL124
CS-113
gudobutrol
Gsdobutrol
Gadobutrol
138071-82-6
Ggadobutrol
gallium 10-(1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-tricarboxylate
gadolinium(III) 2,2',2''-(10-((2R,3S)-1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
GadoliniuM,[10-[2,3-dihydroxy-1-(hydroxyMethyl)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-kN1,kN4,kN7,kN10,kO1,kO4,kO7]- | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C18H31N4O9.Gd | [MDL Number]
MFCD00911649 | [MOL File]
138071-82-6.mol | [Molecular Weight]
604.712 |
| Chemical Properties | Back Directory | [Melting point ]
>264°C (dec.) | [density ]
1.3 g/mL at 37 °C | [storage temp. ]
Refrigerator | [solubility ]
Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [PH]
6.6-8 | [InChIKey]
ZPDFIIGFYAHNSK-IWEVFNEWNA-K | [SMILES]
N1(CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1)[C@H](CO)[C@H](O)CO.[Gd+3] |&1:24,27,r| |
| Hazard Information | Back Directory | [Uses]
Gadobutrol is a gadolinium-based MRI contrast agent (GBCA). | [Mechanism of action]
In the central nervous system, Gadobutrol works by highlighting any areas with disrupted blood brain barrier (BBB) and/or abnormal vascularity. In breast tissue, Gadobutrol exposes the presence and extent of malignant breast disease. | [Side effects]
Side effects of Gadobutrol are uncommon but may include: headache,
nausea,
vomiting,
feeling unwell (malaise),
dizziness,
abnormal or unpleasant taste in your mouth,
feeling hot,
numbness or tingly feeling,
itching or rash,
skin redness, or
injection site reactions (cold feeling, warmth, pain, or burning). Its more serious side effects include: urinating less than usual or not at all; drowsiness, confusion, mood changes, increased thirst, loss of appetite; swelling, weight gain, shortness of breath; seizures (convulsions); breathing problems; pounding heartbeats or fluttering in your chest; or severe pain, burning, or irritation around the IV needle. | [Dosage]
Gadobutrol is given as an infusion into a vein. The recommended dose of Gadobutrol for adult and pediatric patients (including term neonates) is 0.1 mL/kg body weight (0.1 mmol/kg). | [Waste Disposal]
Expired or waste pharmaceuticals shall carefully take into consideration
applicable DEA, EPA, and FDA regulations. It is not appropriate to
dispose by flushing the pharmaceutical down the toilet or discarding to
trash. If possible return the pharmaceutical to the manufacturer for
proper disposal being careful to properly label and securely package the
material. Alternatively, the waste pharmaceutical shall be labeled,
securely packaged and transported by a state licensed medical waste
contractor to dispose by burial in a licensed hazardous or toxic waste
landfill or incinerator. |
|
|