| Identification | Back Directory | [Name]
Meglumine | [CAS]
6284-40-8 | [Synonyms]
Meglumin
MeguMine
MEGLUMINE
Methylglucamin
N-Methyl-D-Glu
MEGLUMINE, USP
MegluMine (AS)
Methylglucamine
N-METHYLGLUCAMINE
Methylglucamine,99%
MegluMine,USP,BP,EP
N-METHYL-D-GLUCAMINE
N-METHYL-D-GLUCANINE
N-MethylglucaMine USP
D(-)-N-METHYLGLUCAMINE
N-METHYL-D(-)-GLUCAMINE
N-METHYLCYCLOHEXALAMINE
Meglumine (500 mg) (AS)
N-METHYL-D-GLUCAMINE USP
N-Methyl-D-Glucamine>99%
MeglumineAntimoniateBase
METHYL GLUCAMINE MEGLUMINE
MEGLUMINE(N-METHYLGLUCAMINE)
N-MethylglucaMin (MegluMine)
N-Methylglucamine (Meglumine)
1-DEOXY-1-METHYLAMINOSORBITOL
1-Deoxy-1-(methylamino)hexitol
1-DEOXY-1-(METHYLAMINO)GLUCITOL
N-Methyl-D-glucaMine, 99% 100GR
N-Methyl-D-glucaMine, 99% 2.5KG
N-Methyl-D-glucaMine, 99% 500GR
N-Methyl-D-glucaMine , 99.0%(T)
1-Methylamino-1-deoxy-D-glucitol
D-1-Deoxy-1-(methylamino)glucitol
1-deoxy-1-(methylamino)-d-glucito
1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL
1-(Methylamino)-1-deoxy-D-glucitol
N-Methyl-D-glucamine
N-Methyl-D-Glucamine(Or) Meglumine
D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)-
Glucitol, 1-deoxy-1-(methylamino)-, D-
D(-)-N-METHYLGLUCAMINE FOR RESOLUTION OF
N-Methyl-D-glucaMine 99.0-100.5% (titration)
N-Methyl-D-glucaMine ReagentPlus(R), >=99.0% (T)
N-Methyl-D-glucamine Vetec(TM) reagent grade, 99%
(2R,3R,4R,5S)-6-(MethylaMino)hexane-1,2,3,4,5-pentaol
D(-)-N-Methylglucamine for resolution of racemates for synthesis
Meglumine, 1-Deoxy-1-(methylamino)-D-glucitol, (2R,3R,4R,5S)-6-Methylaminohexane-1,2,3,4,5-pentaol, 1-Deoxy-1-methylaminosorbitol | [EINECS(EC#)]
228-506-9 | [Molecular Formula]
C7H17NO5 | [MDL Number]
MFCD00004707 | [MOL File]
6284-40-8.mol | [Molecular Weight]
195.21 |
| Chemical Properties | Back Directory | [Appearance]
white to almost white crystalline powder | [Melting point ]
129-131.5 °C(lit.)
| [alpha ]
-16.5 º (c=10, H2O, on dry sub) | [Boiling point ]
331.88°C (rough estimate) | [density ]
1.2669 (rough estimate) | [refractive index ]
-16.5 ° (C=2, H2O) | [RTECS ]
LZ4295770 | [storage temp. ]
Store below +30°C. | [solubility ]
H2O: 0.1 g/mL, clear, colorless
| [form ]
Crystalline Powder | [pka]
pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate) | [color ]
White to almost white | [PH]
11 (10g/l, H2O, 20℃) | [optical activity]
[α]20/D 16.5±0.5°, c = 2% in H2O | [Water Solubility ]
100 g/100 mL (25 ºC) | [Sensitive ]
Air Sensitive & Hygroscopic | [Merck ]
14,6078 | [BRN ]
385906 | [InChIKey]
MBBZMMPHUWSWHV-VZFHVOOUSA-N | [LogP]
-3.370 (est) | [NIST Chemistry Reference]
N-methylglucamine(6284-40-8) | [EPA Substance Registry System]
D-Glucitol, 1-deoxy-1-(methylamino)-(6284-40-8) |
| Hazard Information | Back Directory | [Chemical Properties]
white to almost white crystalline powder | [Uses]
antiinflammatory | [Uses]
excipient in cosmetics and X-ray contrast media | [Definition]
ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi
e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis. | [Production Methods]
Meglumine is prepared by the imination of glucose and monomethylamine,
in an alcoholic solution, followed by catalytic
hydrogenation. | [Brand name]
Renovue
(Bracco). | [General Description]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Meglumine is a glucose-derived secondary amine which is widely used as an excipient in pharmaceutical formulations. | [Pharmaceutical Applications]
Meglumine is an organic base used as a pH-adjusting agent and
solubilizing agent, primarily in the preparation of soluble salts of
iodinated organic acids used as X-ray contrast media. | [Safety]
Meglumine is widely used in parenteral pharmaceutical formulations
and is generally regarded as a nontoxic material at the levels
usually employed as an excipient.
LD50 (mouse, IP): 1.68 g/kg | [storage]
Meglumine does not polymerize or dehydrate unless heated above
150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a
cool, dry place. Meglumine should not be stored in aluminum
containers since it reacts to evolve hydrogen gas; it discolors if
stored in containers made from copper or copper alloys. Stainless
steel containers are recommended. | [Purification Methods]
Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.] | [Incompatibilities]
Incompatible with aluminum, copper, mineral acids, and oxidizing
materials. Differential scanning calorimetry studies suggest meglumine
is incompatible with glipizide. | [Regulatory Status]
Included in the FDA Inactive Ingredients Database (injections; oral
tablets). Included in parenteral medicines licensed in the UK. |
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