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ChemicalBook--->CAS DataBase List--->1369761-01-2

1369761-01-2

1369761-01-2 Structure

1369761-01-2 Structure
IdentificationBack Directory
[Name]

Cerdulatinib HCl salt
[CAS]

1369761-01-2
[Synonyms]

Cerdulatinib HCl
Cerdulatinib HCl salt
PRT2070 hydrochloride
PRT062070 hydrochloride
Cerdulatinib hydrochloride
Cerdulatinib HCl salt USP/EP/BP
Cerdulatinib (PRT062070, PRT2070)
4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide,hydrochloride (1:1)
[Molecular Formula]

C20H28ClN7O3S
[MDL Number]

MFCD28348366
[MOL File]

1369761-01-2.mol
[Molecular Weight]

481.999
Chemical PropertiesBack Directory
[storage temp. ]

Inert atmosphere,2-8°C
[solubility ]

DMSO:20.0(Max Conc. mg/mL);41.49(Max Conc. mM)
[form ]

Solid
[color ]

Light brown to brown
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Spectrum DetailBack Directory
[Spectrum Detail]

Cerdulatinib HCl salt(1369761-01-2)1HNMR
Hazard InformationBack Directory
[Biological Activity]

Cerdulatinib (PRT-062070, PRT2070) hydrochloride is an orally active multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 for JAK1/JAK2/JAK3/TYK2 and Syk, respectively nM and 32 nM. Also inhibits 19 other kinases tested with IC50s below 200 nM.
[in vitro]

Cerdulatinib affects BCR-mediated B cell activation through dual inhibition of SYK and JAK in human whole blood from normal donors. As a dual SYK/JAK inhibitor, Cerdulatinib significantly reduced cell viability in a subset of NHL cell lines and induced apoptosis in NHL cell lines with BCR signaling.

[in vivo]

In a rat collagen-induced arthritis model, Cerdulatinib (5 mg/kg po) significantly improved inflammatory infiltration of synovium and articular cartilage integrity. In addition, cerdulatinib also blocked BCR-induced B cell activation and splenomegaly in mice.
[target]

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> ARK5
(Cell-free assay)
TargetValue
TYK2
(Cell-free assay)
0.5 nM
MST1
(Cell-free assay)
4 nM
4 nM
MLK1
(Cell-free assay)
5 nM
Fms
(Cell-free assay)
5 nM
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