| Identification | More | [Name]
5-Amino-2-nitrobenzoic acid | [CAS]
13280-60-9 | [Synonyms]
2-NITRO-5-AMINOBENZOIC ACID
3-AMINO-6-NITROBENZOIC ACID
3-CARBOXY-4-NITROANILINE
5-AMINO-2-NITROBENZOIC ACID
ANBA
TIMTEC-BB SBB008583
Benzoic acid, 5-amino-2-nitro-
5-AMINO-2-NITROBENZOIC ACID (PURIFIED)[FOR GAMMA-GT] 99+%
5-AMINO-2-NITROBENZOIC ACID 99+%
5-Amino-2-nitrobenzoic acid, 99 % (HPLC)
5-Amino-2-nitrobenzoic Acid (Purified) [for gamma-GT] | [EINECS(EC#)]
236-283-4 | [Molecular Formula]
C7H6N2O4 | [MDL Number]
MFCD00035748 | [Molecular Weight]
182.13 | [MOL File]
13280-60-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow Powder | [Melting point ]
236-238 °C (lit.) | [Boiling point ]
481.3±35.0 °C(Predicted) | [density ]
1.568±0.06 g/cm3(Predicted) | [vapor pressure ]
0-0Pa at 20-50℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO, Methanol | [form ]
Solid | [pka]
2.28±0.25(Predicted) | [color ]
Yellow-Brown | [Water Solubility ]
Insoluble | [BRN ]
2107512 | [InChIKey]
KZZWQCKYLNIOBT-UHFFFAOYSA-N | [LogP]
-1.48 at pH7 | [Surface tension]
70.53mN/m at 1g/L and 20℃ | [CAS DataBase Reference]
13280-60-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
29224999 |
| Hazard Information | Back Directory | [Description]
5-Amino-2-nitrobenzoic acid(13280-60-9) is a reagent used in preparation of polymer-bound diazonium salts and insulin receptor tyrosine kinase activator. It is also used in 2-component dendritic chain reactions and activation of hydrophobic dendrimers.
| [Chemical Properties]
Yellow Powder | [Uses]
Reactant for:
- Two-component dendritic chain reactions
- Enzymic activation of hydrophobic self-immolative dendrimers
- Preparation of insulin receptor tyrosine kinase activator
- Preparation of polymer-bound diazonium salts using Merrifield resin-bound piperazine
| [Application]
5-Amino-2-nitrobenzoic acid(13280-60-9) is a drug that has been shown to inhibit the activity of proteases. It has been used to detect the presence of protease activity in urine samples, as well as to study the inhibition of protease activity by other drugs. It is an inhibitor of chymotrypsin, trypsin, and elastase. This drug has been shown to be effective in inhibiting these enzymes at low concentrations, with a detection sensitivity of approximately 0.1 μM. It inhibits the growth of bacteria by binding to them and preventing protein synthesis. The compound also inhibits the enzyme dihydrolipoamide dehydrogenase in mitochondria, which is required for cellular respiration and energy production.
| [Purification Methods]
Crystallise the acid from water. [Beilstein 14 III 1021.] |
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