| Identification | More | [Name]
4-Nitrophenyl chloroformate | [CAS]
7693-46-1 | [Synonyms]
4-NITROPHENYL CARBONOCHLORIDATE
4-NITROPHENYL CHLOROCARBONATE
4-NITROPHENYL CHLOROFORMATE
CARBONOCHLORIDIC ACID, 4-NITROPHENYL ESTER
CHLOROFORMIC ACID 4-NITROPHENYL ESTER
CHLOROFORMIC ACID P-NITROPHENYL ESTER
NITROPHENYL(4-) CHLOROFORMATE
PARA-NITROPHENYL CHLOROFORMATE
P-NITROPHENYL CHLOROCARBONATE
P-NITROPHENYL CHLOROFORMATE
PNPCF
4-Nitrophenyl chloridocarbonate
Formic acid, chloro-, p-nitrophenyl ester
p-Nitrophenoxycarbonyl chloride
4-Nitrophenylchloroformate,97%
p-Nitrophenyl chloroformate-activated Agarose
(4-Nitrophenoxy)carbonyl chloride
p-Nitrophenol chloroformate
4-Nitrophenyl chloroformate ,98%
1-[(Chlorocarbonyl)oxy]-4-nitrobenzene | [EINECS(EC#)]
231-706-9 | [Molecular Formula]
C7H4ClNO4 | [MDL Number]
MFCD00007321 | [Molecular Weight]
201.56 | [MOL File]
7693-46-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Cream solid | [Melting point ]
77-79 °C(lit.)
| [Boiling point ]
159-162 °C19 mm Hg(lit.)
| [density ]
1.5719 (rough estimate) | [refractive index ]
1.6000 (estimate) | [Fp ]
>110°C | [storage temp. ]
2-8°C
| [solubility ]
Soluble in acetone, chloroform, acetone, toluene and benzene. | [form ]
isopropanol suspension
| [color ]
White to yellow-beige | [Stability:]
Stable. Incompatible with strong bases, acids. Combustible. | [Water Solubility ]
decomposes | [Sensitive ]
Lachrymatory | [Detection Methods]
GC,NMR | [BRN ]
518127 | [CAS DataBase Reference]
7693-46-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Carbonochloridic acid, 4-nitrophenyl ester(7693-46-1) | [Storage Precautions]
Moisture sensitive | [EPA Substance Registry System]
7693-46-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C,T,Xi,F | [Risk Statements ]
R34:Causes burns.
R36/37:Irritating to eyes and respiratory system .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R41:Risk of serious damage to eyes.
R36/37/38:Irritating to eyes, respiratory system and skin .
R11:Highly Flammable. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S38:In case of insufficient ventilation, wear suitable respiratory equipment .
S36:Wear suitable protective clothing .
S16:Keep away from sources of ignition-No smoking .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [F ]
19-21 | [Hazard Note ]
Toxic/Corrosive/Lachrymator | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29159020 |
| Hazard Information | Back Directory | [Chemical Properties]
Cream solid | [Uses]
4-Nitrophenyl Chloroformate is an ester of chloroformic acid used in the immobilization of enzymes and other biomolecules. | [Application]
4-Nitrophenyl chloroformate is used as:A coupling agent to link the drug molecule with the polyrotaxane carrier molecule.As
an activated ester reagent that enables the covalent coupling of a
peptide onto a macromer, such as oligo(poly(ethylene glycol) fumarate)
(OPF). | [Description]
4-Nitrophenyl chloroformate, also known as p-nitrophenyl chloroformate,
is a coupling agent used in the synthesis of ureas, carbamates, and
carbonates. It is also used as a building block in solid-phase peptide
synthesis (SPPS) to obtain altered side chain functionalities in
peptides. | [reaction suitability]
reaction type: Carbonylations |
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