| Identification | More | [Name]
Dimethyl 2-oxoglutarate | [CAS]
13192-04-6 | [Synonyms]
2-KETOGLUTARIC ACID DIMETHYL ESTER
2-OXOGLUTARIC ACID DIMETHYL ESTER
2-Oxo-pentanedioic acid dimethyl ester
DIMETHYL 2-KETOGLUTARATE
DIMETHYL 2-OXOGLUTARATE
DIMETHYL OXOGLUTARATE
ALPHA-Ketoglutaric acid dimethyl ester
2-KETOGLUTARIC ACID DIMETHYL ESTER (ALPHA-) 95+%
α-Ketoglutaric acid dimethyl ester
Dimethyl 2-oxopentanedioate | [Molecular Formula]
C7H10O5 | [MDL Number]
MFCD00048052 | [Molecular Weight]
174.15 | [MOL File]
13192-04-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Slight Yellow Liquid | [Boiling point ]
90-95 °C0.4 mm Hg(lit.)
| [density ]
1.203 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.439(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
-20°C | [solubility ]
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml | [form ]
clear liquid | [color ]
Colorless to Light yellow to Light orange | [CAS DataBase Reference]
13192-04-6(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Slight Yellow Liquid | [Uses]
Dimethyl 2-oxoglutarate may be used to synthesize the conformationally constrained PNA (peptide nucleic acid) -monomer capable of binding thymine in a triplex motif. It may be used in the synthesis of 4-aryl kainic acid analogs, via highly stereoselective Michael addition reaction with nitrostyrene. | [Definition]
ChEBI: Dimethyl 2-oxoglutarate is an oxo carboxylic acid. | [General Description]
Dimethyl 2-oxoglutarate is a key intermediate formed during the Krebs cycle and an important nitrogen transporter in the biological metabolic pathways. The electrochemical behavior of dimethyl-2-oxoglutarate has been investigated by cyclic voltammetry, square wave voltammetry and differential pulse voltammetry using a glassy carbon electrode. | [in vivo]
Dimethyl 2-oxoglutarate (i.p.) decreases cardiac maladaptive autophagy induced by thoracic aortic constriction (TAC), ameliorating TAC-induced pathological remodeling, ventricular hypertrophy and fibrosis, and reduction in contractile performance in mice[3].
| [IC 50]
Microbial Metabolite | [storage]
-20°C |
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