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ChemicalBook--->CAS DataBase List--->125562-30-3

125562-30-3

125562-30-3 Structure

125562-30-3 Structure
IdentificationBack Directory
[Name]

m-PEG9-bromide
[CAS]

125562-30-3
[Synonyms]

mPEG9-Br
m-PEG9-bromide
Bromo-PEG9-methoxy
Methyl-PEG9-bromide, M-Peg9-bromide, MPEG9-BR
28-Bromo-2,5,8,11,14,17,20,23,26-nonaoxaoctacosane
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosane, 28-bromo-
[Molecular Formula]

C19H39BrO9
[MDL Number]

MFCD28950767
[MOL File]

125562-30-3.mol
[Molecular Weight]

491.41
Chemical PropertiesBack Directory
[Boiling point ]

498.1±40.0 °C(Predicted)
[density ]

1.190±0.06 g/cm3(Predicted)
[solubility ]

Soluble in Water, DMSO, DCM, DMF
[form ]

Liquid
[color ]

Yellow to brown
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
Hazard InformationBack Directory
[Description]

m-PEG9-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
[Uses]

m-PEG9-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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