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ChemicalBook--->CAS DataBase List--->110429-45-3

110429-45-3

    110429-45-3 Structure

    110429-45-3 Structure
    IdentificationBack Directory
    [Name]

    Triethylene Glycol 2-Bromoethyl Methyl Ether
    [CAS]

    110429-45-3
    [Synonyms]

    mPEG4-Br
    m-PEG4-bromo
    m-PEG4-bromide
    Br-(CH2CH2O)4-Me
    Bromo-PEG4-methoxy
    Methyl-PEG4-bromide
    1-Bromo-3,6,9,12-tetraoxatridecane
    13-Bromo-2,5,8,11-tetraoxatridecane
    2,5,8,11-Tetraoxatridecane, 13-bromo-
    Triethylene Glycol 2-Bromoethyl Methyl Ether
    2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide
    2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide 1-Bromo-3,6,9,12-tetraoxatridecane
    [Molecular Formula]

    C9H19BrO4
    [MDL Number]

    MFCD12545963
    [MOL File]

    110429-45-3.mol
    [Molecular Weight]

    271.149
    Chemical PropertiesBack Directory
    [Boiling point ]

    296.3±25.0 °C(Predicted)
    [density ]

    1.256±0.06 g/cm3(Predicted)
    [refractive index ]

    1.4620 to 1.4660
    [storage temp. ]

    2-8°C
    [form ]

    clear liquid
    [color ]

    White to Yellow to Green
    [CAS DataBase Reference]

    110429-45-3
    Safety DataBack Directory
    [HS Code ]

    2909.19.6000
    Hazard InformationBack Directory
    [Description]

    m-PEG4-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
    [Biological Activity]

    Triethylene Glycol 2-Bromoethyl Methyl Ether is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs) of trastuzumab (HY-P9907). It was placed distal to the monomethyl auristatin E (MMAE) payload to generate ADCs with altered hydrophilicity, antigen binding and in vitro potency. Tetraethylene glycol monotosylate can also be used as a linker of PROTAC, which can be used for the synthesis of PROTAC.
    [in vitro]

    ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

    [target]

    Cleavable

    PEGs

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