| Identification | Back Directory | [Name]
NONAETHYLENE GLYCOL MONOMETHYL ETHER | [CAS]
6048-68-6 | [Synonyms]
MPEG-9
MPEG9-OH
m-PEG9-alcohol
Methyl-PEG9-alcohol
O-metil-nonaetilenglicol
NONAETHYLENE GLYCOL MONOMETHYL ETHER
NonaethyleneGlycolMonomethylEther>
3,6,9,12,15,18,21,24,27-Nonaoxaoctacosan-1-ol
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol
2,5,8,11,14,17,20,23,26-Nonaoxa-28-octacosanol
2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol | [Molecular Formula]
C19H40O10 | [MDL Number]
MFCD06797148 | [MOL File]
6048-68-6.mol | [Molecular Weight]
428.51 |
| Chemical Properties | Back Directory | [Melting point ]
14 °C | [Boiling point ]
170 °C(Press: 0.01 Torr) | [density ]
1.10 | [refractive index ]
1.4570 to 1.4620 | [form ]
clear liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to Light yellow to Light orange | [InChI]
InChI=1S/C19H40O10/c1-21-4-5-23-8-9-25-12-13-27-16-17-29-19-18-28-15-14-26-11-10-24-7-6-22-3-2-20/h20H,2-19H2,1H3 | [InChIKey]
VVHAVLIDQNWEKF-UHFFFAOYSA-N | [SMILES]
C(O)COCCOCCOCCOCCOCCOCCOCCOCCOC |
| Hazard Information | Back Directory | [Description]
m-PEG9-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media. | [Definition]
ChEBI: Nonaethylene glycol monomethyl ether is nonaethylene glycol in which one of the hydroxy groups is substituted by methoxy. It is functionally related to a nonaethylene glycol. | [in vitro]
Nonaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used to synthesize PROTACs.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase, and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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