| Identification | Back Directory | [Name]
ML-109 | [CAS]
1186649-91-1 | [Synonyms]
ML-109
N-[4-[[2-Methoxy-5-[1,2,3,4-tetrahydro-5-hydroxy-4-oxo-3-(phenylmethyl)-2-quinazolinyl]phenyl]methoxy]phenyl]acetamide
Acetamide, N-[4-[[2-methoxy-5-[1,2,3,4-tetrahydro-5-hydroxy-4-oxo-3-(phenylmethyl)-2-quinazolinyl]phenyl]methoxy]phenyl]- | [Molecular Formula]
C31H29N3O5 | [MDL Number]
MFCD31746908 | [MOL File]
1186649-91-1.mol | [Molecular Weight]
523.58 |
| Chemical Properties | Back Directory | [Boiling point ]
810.1±65.0 °C(Predicted) | [density ]
1.300±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:83.0(Max Conc. mg/mL);158.5(Max Conc. mM) | [form ]
Solid | [pka]
8.66±0.40(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM. | [Definition]
ChEBI: N-[4-[[5-[5-hydroxy-4-oxo-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]-2-methoxyphenyl]methoxy]phenyl]acetamide is a member of quinazolines. | [References]
[1] Neumann S, et al. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12471-6. DOI:10.1073/pnas.0904506106 |
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