| Identification | Back Directory | [Name]
dehydromiltirone | [CAS]
116064-77-8 | [Synonyms]
dehydromiltirone
Dehydrorosmariquinone
1,2-Didehydromiltirone
Levoceitrizine Hcl USP/EP/BP
1,5,7,9,13-Abietapentaene-11,12-dione
20-Norabieta-1,5,7,9,13-pentene-11,12-dione
2-Isopropyl-8,8-dimethyl-7,8-dihydrophenanthrene-3,4-dione
7,8-Dihydro-2-isopropyl-8,8-dimethylphenanthrene-3,4-dione
7,8-Dihydro-8,8-dimethyl-2-(1-methylethyl)-3,4-phenanthrenedione
3,4-Phenanthrenedione, 7,8-dihydro-8,8-dimethyl-2-(1-methylethyl)- | [Molecular Formula]
C19H20O2 | [MOL File]
116064-77-8.mol | [Molecular Weight]
280.36 |
| Chemical Properties | Back Directory | [Melting point ]
71-75℃ (hexane ) | [Boiling point ]
423.8±45.0 °C(Predicted) | [density ]
1.116±0.06 g/cm3 (20 ºC 760 Torr) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [color ]
Red |
| Hazard Information | Back Directory | [Uses]
Dehydromiltirone displays inhibitory effect against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). | [in vivo]
Dehydromiltirone (50-200?mg/kg, p.o.; daily; for five consecutive days) protects the liver from CCl4-induced injury. Dehydromiltirone reduces the increase in the proinflammatory cytokines TNF-α, IL-1 and IL-6, indicating an effect on alleviating liver inflammation[1]. | Animal Model: | Rat model of acute liver injury[1] | | Dosage: | 50 mg/kg, 100 mg/kg, and 200?mg/kg | | Administration: | p.o.; daily; for five consecutive days | | Result: | Protected liver from CCl4-induced damage. |
| [target]
NOS | COX | NF-kB | PI3K | Akt | NO | TNF-α | IL Receptor | IkB | IKK |
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