| Identification | More | [Name]
Tris(2-chloroethyl) phosphate | [CAS]
115-96-8 | [Synonyms]
AURORA KA-1645
PHOSPHORIC ACID TRIS(2-CHLOROETHYL) ESTER
TCEP
TRI-2-CHLOROETHYL PHOSPHATE
Trichlorethyl phosphate
TRICHLOROETHYL PHOSPHATE
TRIS(2-CHLOROETHYL)PHOSPHATE
TRIS(BETA-CHLOROETHYL) PHOSPHATE
2-Chloroethanol phosphate
2-Chloro-ethanol phosphate (3:1)
2-chloroethanolphosphate
2-chloro-ethanophosphate(3:1)
3CF
ai3-15023
antiblaze100
Celluflex
Celluflex CEF
celluflexcef
Disflamoll TCA
disflamolltca | [EINECS(EC#)]
204-118-5 | [Molecular Formula]
C6H12Cl3O4P | [MDL Number]
MFCD00000967 | [Molecular Weight]
285.49 | [MOL File]
115-96-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear, transparent liquid. Slightly water soluble. Combustible. | [Melting point ]
-51 °C | [Boiling point ]
192 °C/10 mmHg (lit.) | [density ]
1.39 g/mL at 25 °C(lit.)
| [vapor pressure ]
<10 mm Hg ( 25 °C)
| [refractive index ]
n20/D 1.472(lit.)
| [Fp ]
450 °F
| [storage temp. ]
2-8°C | [solubility ]
H2O: soluble7.82g/L | [form ]
Liquid | [color ]
Clear colorless | [Stability:]
Stable. Incompatible with strong bases, strong oxidizing agents. | [Water Solubility ]
7 g/L (20 ºC) | [InChIKey]
HQUQLFOMPYWACS-UHFFFAOYSA-N | [LogP]
1.7 at 20℃ | [CAS DataBase Reference]
115-96-8(CAS DataBase Reference) | [IARC]
3 (Vol. 48, 71) 1999 | [NIST Chemistry Reference]
Phosphoric acid, tri-2-chloroethyl ester(115-96-8) | [EPA Substance Registry System]
115-96-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N | [Risk Statements ]
R22:Harmful if swallowed.
R40:Limited evidence of a carcinogenic effect.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 2810 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
KK2450000
| [HazardClass ]
9 | [PackingGroup ]
III | [HS Code ]
29199000 | [Safety Profile]
Poison by
intraperitoneal route. Moderately toxic by
ingestion. Experimental reproductive
effects. Questionable carcinogen with
experimental tumorigenic data. A skin and
eye irritant. Combustible when exposed to
heat or flame. When heated to
decomposition it emits very toxic fumes of
POx and Cl-. See also PHOSPHATES,
CHLORIDES, and ESTERS. | [Hazardous Substances Data]
115-96-8(Hazardous Substances Data) | [Toxicity]
LD50 oral in rat: 1230mg/kg |
| Hazard Information | Back Directory | [General Description]
Odorless clear liquid. Neutral pH. | [Reactivity Profile]
TRIS(2-CHLOROETHYL) PHOSPHATE(115-96-8) is incompatible with strong oxidizing agents and strong bases. | [Air & Water Reactions]
Slightly water soluble. | [Fire Hazard]
This chemical is combustible. | [Chemical Properties]
Clear, transparent liquid. Slightly water soluble. Combustible. | [Uses]
Tris(2-chloroethyl) phosphate was used in dynamic air sampling of airborne organophosphate triesters using a solid-phase microextraction device. | [Uses]
A human urinary organophosphate flame retardant metabolite. | [Definition]
ChEBI: A trialkyl phosphate that is the tris(2-chloroethyl) ester of phosphoric acid. | [Toxicology]
The toxicological data of tris(2-chloroethyl) phosphate, LD50 values of 390-1410 mg/kg (and more than 2000 mg/kg in one study), have been reported for rats following oral administration. The substance is nonirritating to very mildly irritating to the skin and mucous membranes. It was not sensitizing to the skin in guinea pigs. Subchronic administration of tris(2- chloroethyl) phosphate caused increased liver weight in rats and mice. Additionally, rats showed increased kidney weights and degenerative changes in the hippocampus region of the brain. Results of mutagenicity studies on tris(2- chloroethyl) phosphate are not consistent, but the majority of tests were negative. Results of carcinogenicity studies suggest that tris(2-chloroethyl) phosphate possesses a weak tumorigenic activity, possibly via an epigenetic mechanism. When pregnant rats were treated with tris(2- chloroethyl) phosphate, toxic effects were found in the mother, but no fetotoxic or teratogenic effects were observed. Impairment of reproduction was observed in a two-generation study in mice.
|
|
|