| Identification | More | [Name]
Pentanedial | [CAS]
111-30-8 | [Synonyms]
1,5-PENTANEDIAL
FIXATIVE 15960
FIXATIVE 15970
FIXATIVE 15980
GLUTARALDEHYDE
GLUTARDIALDEHYDE
GLUTARIC DIALDEHYDE
PANTHANEDIAL
PENTANE-1,5-DIAL
1,3-diformalpropane
1,3-Diformylpropane
1,5-Pentanedione
aldehydglutarowy
Aldesan
aldesen
Alhydex
Aqucar
Cidex
Cidex 7
Coldcide-25 microbiocide | [EINECS(EC#)]
203-856-5 | [Molecular Formula]
C5H8O2 | [MDL Number]
MFCD00007025 | [Molecular Weight]
100.12 | [MOL File]
111-30-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Glutaraldehyde is a colorless liquid with a
pungent odor, which readily changes to a glossy polymer.
The Odor Threshold is 0.04 ppm (NY) and 0.2 ppm (NJ). | [Melting point ]
-15 °C
| [Boiling point ]
100 °C
| [density ]
1.058 g/mL at 20 °C | [vapor density ]
1.05 (vs air) | [vapor pressure ]
15 mmHg ( 20 °C) | [refractive index ]
n20/D 1.450
| [Fp ]
100°C | [storage temp. ]
2-8°C
| [solubility ]
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Solution | [color ]
Clear to slight haze | [Specific Gravity]
1.06 | [Odor]
pungent aldehyde odor | [PH]
>3.0 (H2O, 20°C) | [Water Solubility ]
miscible | [Merck ]
14,4472 | [BRN ]
605390 | [Exposure limits]
Ceiling (ACGIH) 0.8 mg/m3 (0.2 ppm). | [Stability:]
Light Sensitive | [Contact allergens]
Glutaraldehyde is a well-know sensitizer in cleaners
and health workers. It can also be found in X-ray
developers or in cosmetics. | [InChIKey]
SXRSQZLOMIGNAQ-UHFFFAOYSA-N | [LogP]
-0.180 (est) | [Uses]
glutaral (glutardialdehyde) is a broad-spectrum preservative that can cause skin irritation. This is an amino acid occurring in green sugar beets. | [CAS DataBase Reference]
111-30-8(CAS DataBase Reference) | [NIST Chemistry Reference]
Glutaral(111-30-8) | [EPA Substance Registry System]
111-30-8(EPA Substance) |
| Questions And Answer | Back Directory | [Uses]
As broad-spectrum antimicrobial cold sterilant/disinfectant for hospital equipment; as tanning agent for leather; as tissue fixative; as cross-linking agent for proteins; as preservative in cosmetics; as therapeutic agent for warts, hyperhidrosis, and dermal mycotic infections; in X ray processing solutions and film emulsion; as a disinfectant in the beauty industry
|
| Hazard Information | Back Directory | [Chemical Properties]
clear solution | [Uses]
Contains variable amounts of polymer.1 | [Uses]
Cross-linking agent for gelatin,1,2 poly(vinyl alcohol),3 and polyheptapeptides.4 | [Uses]
Glutaraldehyde is used to disinfect medical and dental equipment. Glutaraldehyde is also used for industrial water treatment and as a preservative. | [Uses]
Recommended for techniques demanding high purity. | [Definition]
ChEBI: A dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5. | [General Description]
Light yellow liquid. Mixes with water. | [Reactivity Profile]
GLUTARALDEHYDE may discolor on exposure to air. GLUTARALDEHYDE SOLUTION(111-30-8) polymerizes on heating. This chemical is incompatible with strong oxidizing agents. GLUTARALDEHYDE SOLUTION(111-30-8) polymerizes in the presence of water. | [Air & Water Reactions]
Polymerizes in the presence of water. | [Health Hazard]
Contact with liquid causes severe irritation of eyes and irritation of skin. Chemical readily penetrates skin in harmful amounts. Ingestion causes irritation of mouth and stomach. | [Potential Exposure]
Glutaraldehyde is used in leather
tanning; in embalming fluids; as a germicide; as a
cross-linking agent for protein and polyhydroxy materi als; as a fixative for tissues; and as an intermediate.
Buffered solutions are used as antimicrobial agents in
hospitals. | [Fire Hazard]
Literature sources indicate that this chemical is nonflammable. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
30 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, includ ing resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit. | [Shipping]
UN2810 Toxic liquids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. | [Incompatibilities]
Water contact forms a polymer solution.
A strong reducing agent. Incompatible with strong acids;
caustics, ammonia, amines, and strong oxidizers. Note:
Alkaline solutions of glutaraldehyde (i.e., activated glutar aldehyde) react with alcohol, ketones, amines, hydrazines,
and proteins. | [Description]
Glutaraldehyde is a well-known sensitizer among
cleaners and health workers. It is also found in X-ray
developers products.
| [Waste Disposal]
Dissolve or mix the material
with a combustible solvent and burn in a chemical incinera tor equipped with an afterburner and scrubber. All federal,
state, and local environmental regulations must be observed. | [Synthesis Reference(s)]
Tetrahedron, 48, p. 3503, 1992 DOI: 10.1016/S0040-4020(01)88489-1 | [Flammability and Explosibility]
Nonflammable | [Biochem/physiol Actions]
Glutaraldehyde is an effective protein crosslinker and finds application in techniques like enzyme immobilisation microscopy, histochemistry and cytochemistry. It exists in different forms under acidic or neutral conditions. It is a biocide widely used as a disinfectant in hospitals and industries and is toxic to aquatic organisms. Its allergic nature leads to hypersensitivity reactions. Contact of glutaraldehyde vapors in endoscopy contributes to Colitis. | [Purification Methods]
Likely impurities are oxidation products-acids, semialdehydes and polymers. It can be purified by repeated washing with activated charcoal (Norit) followed by vacuum filtration, using 15-20g charcoal/100mL of glutaraldehyde solution. Distil it at 60-65o/15mm, discarding the first 5-10%, then dilute with an equal volume of freshly distilled water at 70-75o, using magnetic stirring under nitrogen. The solution is stored at low temperature (3-4o), in a tightly stoppered container, and protected from light. Standardise by titration with hydroxylamine. [Anderson J Histochem Cytochem 15 652 1967, Beilstein 1 IV 3659.] |
| Safety Data | Back Directory | [Hazard Codes ]
T,N,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R42/43:May cause sensitization by inhalation and skin contact .
R34:Causes burns.
R23:Toxic by inhalation.
R22:Harmful if swallowed.
R50:Very Toxic to aquatic organisms.
R23/25:Toxic by inhalation and if swallowed .
R41:Risk of serious damage to eyes.
R37/38:Irritating to respiratory system and skin .
R20/22:Harmful by inhalation and if swallowed . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 2922 8/PG 2
| [WGK Germany ]
3
| [RTECS ]
MA2450000 | [F ]
8-10-23 | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29121990 | [Safety Profile]
Poison by ingestion,
intravenous, and intraperitoneal routes.
Moderately toxic by inhalation, skin contact,
and subcutaneous routes. Experimental
teratogenic and reproductive effects. A
severe eye and human skin irritant. Mutation
data reported. When heated to decomp osition it emits acrid smoke and irritating
fumes. See also ALDEHYDES. | [Hazardous Substances Data]
111-30-8(Hazardous Substances Data) | [Toxicity]
LD50 of 25% soln orally in rats: 2.38 ml/kg; by skin penetration in rabbits: 2.56 ml/kg (Smyth) |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Ethyl vinyl ether-->Acrolein-->Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate-->3,4-Dihydro-2H-pyran-->2-ETHOXY-3,4-DIHYDRO-2H-PYRAN-->1,1,5,5-tetramethoxypentane-->CIS-1,2-CYCLOPENTANEDIOL-->1,2-Cyclopentanediol-->2,2'-TRIMETHYLENEBIS-1,3-DIOXOLANE-->3,4-DIHYDRO-2-METHOXY-2H-PYRAN-->Cyclopentene oxide-->Piperidine | [Preparation Products]
L-Aspartic acid-->graft copolymer PAA-G-PIPA microsphere-->novel anticancer microsphere with multifunction-->Modified glutaraldehyde-->2,2'-(1-Methyl-2,6-piperidinediyl)diacetophenon-->1-(2-NITROPHENYL)PIPERIDINE-->trans-1,2-Cyclopentanediol-->CIS-1-BENZYL-2,6-DICYANOPIPERIDINE |
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