ChemicalBook CAS DataBase List Z-THR(TBU)-OH

Z-THR(TBU)-OH synthesis

10synthesis methods

Product Name:Z-THR(TBU)-OH
CAS Number:16966-09-9
Molecular formula:C16H23NO5
Molecular Weight:309.36

52785-41-8 Synthesis

52785-41-8
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16966-09-9
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Yield: 80.3%

Reaction Conditions:

with sodium hydroxide in water;acetone; pH=10 - 11

Steps:

1.4
4The Z-thr (tbu) -ome 169g was added to 2L beaker, 300Ml of acetone 600Ml, 2mlc / l sodium hydroxide adjusted to pH 10-11 reaction. The reaction is completed, washed with ether 500ml once, add ethyl acetate 800ml, citric acid aqueous solution to adjust the pH in 2-3.300ml washed, 300ml saturated salt water wash. 100G dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to dry granulated ether 500ML to give z-thr (tbu) -oH 130 g, yield 80.3%

References:

Jier Biochemical (Shanghai) Co., Ltd.;Liu Hao;Xu Hongyan CN106631900, 2017, A Location in patent:Paragraph 0015

4378-13-6 Synthesis