ChemicalBook CAS DataBase List Tetrahydrofuran

Tetrahydrofuran synthesis

15synthesis methods

Product Name:Tetrahydrofuran
CAS Number:109-99-9
Molecular formula:C4H8O
Molecular Weight:72.11

Tetrahydrofuran is one of the strongest polar ethers, used as solvent in chemical reactions and extractions. It is a colorless and volatile liquid at room temperature and has an odor similar to ether. Tetrahydrofuran(THF) can be synthesized by uronic acid, which was fed into a reactor filled with zinc-chromium-manganese metal oxide (or palladium) catalyst, and the carbonyl group was removed at 400-420 ° C to form furan; 120 ℃ furan hydrogenation to produce tetrahydrofuran.

5371-52-8 Synthesis

5371-52-8
71 suppliers
$61.60/10MG

109-99-9
1045 suppliers
$9.00/5ml

Yield:109-99-9 100%

Reaction Conditions:

with phosphoric acid;5%-palladium/activated carbon;hydrogen at 100; under 3750.38 - 13501.4 Torr; for 7 h;Autoclave;Reagent/catalyst;Pressure;Temperature;

Steps:

1-5; 8; 9 Example 1

60 g of 2-hydroxytetrahydrofuran (HF), 1.2 g of 5 mass% palladium/activated carbon powder (E1010/W manufactured by Evonik Industries), and 0.6 g of 85% phosphoric acid were placed and mixed in a 100-mL stainless-steel autoclave having a gas introduction port and a sampling port. The pH of the mixture was measured by using a pH test paper strip, manufactured by Toyo Roshi, and found to be 4. The atmosphere in the reactor was replaced with hydrogen and pressurized to 0.5 MPa, and the temperature in the reactor was raised to 100° C. Subsequently, the hydrogen pressure was raised to 1.8 MPa. The mixture was allowed to react for 7 hours. Hydrogen was added during the reaction so as to keep the pressure at 1.8 MPa. Gas chromatography analysis of the reaction mixture after the reaction revealed that the conversion rate of HF was 100% and the yield of tetrahydrofuran (THF) was 100%.

References:

US2020/290983,2020,A1 Location in patent:Paragraph 0048-0052; 0057-0059

98-01-1 Synthesis