Tetracaine synthesis
- Product Name:Tetracaine
- CAS Number:94-24-6
- Molecular formula:C15H24N2O2
- Molecular Weight:264.36
Yield:94-24-6 82.8%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 50; for 5 h;
Steps:
3 Preparation of tetracaine (7)
5.0 g of p-aminobenzoic acid-2-dimethylaminoethyl ester (5) (0.024 mol 1)3.3g1-Bromo-n-Butane(0 · 024mo 1), 10.0g K2C03 (0 · 072mo 1) 50mL N, N-dimethylformamide was placed in 1OOmL three-necked flask, stirred and heated to 50 ° C, the reaction system was maintained at 50 After the reaction was stopped for 5 h, the reaction was stopped and the reaction system was allowed to stand at room temperature. The filtrate was extracted with 50 mL of dichloromethane. The aqueous phase was extracted with 50 mL of dichloromethane. The organic phase was combined, To give 5.3 g of a white solid, yield 82.8%.
References:
CN106518697,2017,A Location in patent:Paragraph 0014
108-01-0
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94-24-6
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108-01-0
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4740-24-3
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94-24-6
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94-09-7
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94-24-6
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