Tenofovir Impurity 37 synthesis
- Product Name:Tenofovir Impurity 37
- CAS Number:161760-03-8
- Molecular formula:C10H15O6PS
- Molecular Weight:294.26
31618-90-3
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Yield:161760-03-8 85.8 %
Reaction Conditions:
with water;sodium hydroxide in tetrahydrofuran at 20;
Steps:
4.a a. Synthesis of compounds 4-2
4-1 (2.3g, 7.1360 mmol, 1.0eq) was added to tetrahydrofuran (27.6 mL) andH2O(9.2 mL), then NaOH (2.85 g, 71.3599 mmol, 10.0 eq), RT reaction 2d. The mixture was concentrated under vacuum reduced pressure, and then column chromatography DCM: MeOH = 10: 1-4: 1, to give 1.8g of colorless oily liquid is compound 4-2, yield: 85.8%.
References:
CN114907401,2022,A Location in patent:Paragraph 0075-0078
