TAK-960 synthesis

10synthesis methods

Product Name:TAK-960
CAS Number:1137868-52-0
Molecular formula:C27H34F3N7O3
Molecular Weight:561.6

1003-03-8 Synthesis

1003-03-8
222 suppliers
$10.00/1g

1137868-52-0
76 suppliers
$49.00/1mg

Yield:-

Steps:

Multi-step reaction with 7 steps
1.1: diethyl ether / 12 h / 20 °C
2.1: chloro-trimethyl-silane; zinc / tetrahydrofuran / 0.33 h / -10 °C
2.2: 3 h / -10 - 20 °C
3.1: sodium hydrogencarbonate / ethyl acetate / 18 h / 0 - 20 °C
4.1: iron; acetic acid / 2 h / 80 °C
5.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C
6.1: hydrogenchloride / ethanol; water / 18 h / Reflux
7.1: O-Benzotriazol-1-yl-N,N,N',N'-bis(tetramethylene)uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

References:

Chen, Shaoqing;Bartkovitz, David;Cai, Jianping;Chen, Yi;Chen, Zhi;Chu, Xin-Jie;Le, Kang;Le, Nam T.;Luk, Kin-Chun;Mischke, Steve;Naderi-Oboodi, Goli;Boylan, John F.;Nevins, Tom;Qing, Weiguo;Chen, Yingsi;Wovkulich, Peter M. [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 2,p. 1247 - 1250]

41838-46-4 Synthesis