ChemicalBook CAS DataBase List Sparfloxacin

Sparfloxacin synthesis

8synthesis methods

Product Name:Sparfloxacin
CAS Number:111542-93-9
Molecular formula:C19H22F2N4O3
Molecular Weight:392.4

1201-31-6 Synthesis

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Yield:-

Steps:

Multi-step reaction with 9 steps
1: 35 percent / fuming HNO₃, H₂SO₄ / 5.5 h / 70 °C
2: oxalyl chloride, DMF / CH₂Cl₂ / 16 h
3: 1.) n-BuLi, dipyridyl / 1.) THF, -30 deg C, 2.) THF, from -78 deg C to -35 deg C, 1 h
4: 95 percent / Ac₂O / 3 h / Heating
5: 2-methyl-propan-2-ol / 3.5 h / 45 °C
6: t-BuOK / 6 h / 60 °C
7: 100 percent / H₂ / RaNi / tetrahydrofuran; ethanol / 12 h / 1034.3 Torr
8: 100 percent / 6 M HCl / 2 h / Heating
9: 70 percent / Et₃N / pyridine / Heating

References:

Domagala;Bridges;Culbertson;Gambino;Hagen;Karrick;Porter;Sanchez;Sesnie;Spense;Szotek;Wemple [Journal of Medicinal Chemistry,1991,vol. 34,# 3,p. 1142 - 1154]