Sitagliptin Defuoro IMpurity 3 synthesis
- Product Name:Sitagliptin Defuoro IMpurity 3
- CAS Number:851307-12-5
- Molecular formula:C15H19F2NO4
- Molecular Weight:315.31
81228-09-3
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$12.00/2 g
851307-12-5
68 suppliers
$172.00/100mg
Yield:-
Steps:
Multi-step reaction with 8 steps
1: (COCl)2; DMF / CH2Cl2
2: 2,4,6-collidine
3: 81 percent / 4 h / Heating
4: 87 percent / AcOH / methanol / 2 h / 40 °C
5: 42 percent / H2 / PtO2 / tetrahydrofuran; methanol / 4654.46 Torr
6: AcOH / Pearlman's catalyst / methanol; H2O
7: Et3N / CH2Cl2
8: 87 percent / aq. LiOH / tetrahydrofuran
References:
Kim, Dooseop;Kowalchick, Jennifer E.;Edmondson, Scott D.;Mastracchio, Anthony;Xu, Jinyou;Eiermann, George J.;Leiting, Barbara;Wu, Joseph K.;Pryor, KellyAnn D.;Patel, Reshma A.;He, Huaibing;Lyons, Kathryn A.;Thornberry, Nancy A.;Weber, Ann E. [Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,# 12,p. 3373 - 3377]
942475-04-9
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851307-12-5
68 suppliers
$172.00/100mg
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945261-73-4
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851307-12-5
68 suppliers
$172.00/100mg
141060-00-6
19 suppliers
$15.00/1g
851307-12-5
68 suppliers
$172.00/100mg