(S)-ropivacaine hydrochloride hydrate synthesis
- Product Name:(S)-ropivacaine hydrochloride hydrate
- CAS Number:132112-35-7
- Molecular formula:C17H26N2O.ClH.H2O
- Molecular Weight:328.88
84057-95-4
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132112-35-7
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$49.00/25mg
Yield:132112-35-7 82%
Reaction Conditions:
with hydrogenchloride;water in acetone; pH=2;Product distribution / selectivity;Heating / reflux;
Steps:
11
About 3 g of Ropivacaine base was dissolved in 10 mL of water and to this solution was added 50 mL of hot acetone and conc. Hydrochloride acid was added slowly with stirring until pH reaches 2 and heated to reflux until the solution becomes clear solution. 20 mL of acetone was added and the precipitated solid was filtered, washed with acetone and dried to give L-Ropivacaine hydrochloride monohydrate 2.9 g, yield 82% Water content: 5.6%
References:
US2006/276654,2006,A1 Location in patent:Page/Page column 5
98717-15-8
236 suppliers
$49.00/25mg
132112-35-7
344 suppliers
$49.00/25mg