(R)-4-BROMOSTYRENE OXIDE synthesis

12synthesis methods

Product Name:(R)-4-BROMOSTYRENE OXIDE
CAS Number:62566-68-1
Molecular formula:C8H7BrO
Molecular Weight:199.04

(R)-2-bromo-1-(4-bromophenyl)ethanol(WXC05605)

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62566-68-1
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Yield: 98%

Reaction Conditions:

with sodium hydroxide in tetrahydrofuran;water at 20; for 1 h;enantioselective reaction;

Steps:

General procedure for the synthesis of chiral styrene oxides
General procedure: For the preparation of chiral styrene oxides, 3 mL NaOH(2 N) was added to α-bromohydrin (0.5 mmol) in 6 mL tetrahydrofuran(THF) and then was sttired at room temperature for 1 h. After completing the reaction, the product was extracted by EtOAc and then purified using column chromatography on silica gel using ethyl acetate/n-hexane gradient to give the desired product in high purity.

References:

Hosseinzadeh, Rahman;Mohadjerani, Maryam;Mesgar, Sakineh [Journal of the Iranian Chemical Society,2019,vol. 16,# 3,p. 583 - 591]