ChemicalBook CAS DataBase List (R)-(-)-3-Hydroxytetrahydrofuran

(R)-(-)-3-Hydroxytetrahydrofuran synthesis

10synthesis methods

Product Name:(R)-(-)-3-Hydroxytetrahydrofuran
CAS Number:86087-24-3
Molecular formula:C4H8O2
Molecular Weight:88.11

(R)-(-)-3-hydroxytetrahydrofuran can be used as organic synthesis intermediate and pharmaceutical intermediate in the process of pharmaceutical synthesis. The (R)-4-chloro-1,3-butanediol in 0.5N hydrochloric acid was heated for 2 hours. The reaction mixture was neutralized with a 50% aqueous solution of sodium hydroxide, and filtrated to give (R)-3-Hydroxytetrahydrofuran, yield: 67%.

70005-88-8
120 suppliers
$55.00/250 mg

86087-24-3
364 suppliers
$8.00/1g

Yield:86087-24-3 99%

Reaction Conditions:

strong acid ion exchange resin (Amberlyst 15, H+ form) in 1,4-dioxane at 100; under 760.051 Torr;Product distribution / selectivity;

Steps:

4
Example 4; 5 g of the catalyst used in Example 1 was loaded into a completely automated continuous fixed-bed reactor made of 316 stainless steel, after which the internal temperature of the reactor was adjusted to 100°C and then a dioxane solution containing 10 wt% of (R)- 1,2,4- butanetriol (optical purity of 99.0%) was fed into the reactor at a WHSV of 2.0 h^~ to thus conduct the reaction.The results of the preparation of (R)-3-tetrahydrofuran are shown in Table 3 below.

References:

SK CORPORATION WO2007/81065, 2007, A1 Location in patent:Page/Page column 6-7

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