ChemicalBook CAS DataBase List Quinaldine

Quinaldine synthesis

13synthesis methods

Product Name:Quinaldine
CAS Number:91-63-4
Molecular formula:C10H9N
Molecular Weight:143.19

High-temperature coal tar contains an average of 0.2% quinaldine. It is recovered from the quinoline base mixture by rectification and hydration. Quinaldine can be synthesized by the Skraup method from aniline and crotonaldehyde with sulfuric acid in the presence of a dehydrogenating agent.

64-17-5 Synthesis

64-17-5
716 suppliers
$10.00/50g

62-53-3 Synthesis

62-53-3
651 suppliers
$10.00/1g

91-63-4
271 suppliers
$21.60/25g

Yield:91-63-4 93%

Reaction Conditions:

with transition metal catalyst;pyridine derviative;acid derviative at 150; for 8 h;Green chemistry;

Steps:

1
Accurately weigh 0.005mmol (l. Lmg) of the transition metal, add 10mL has been put into the magnetic stirrer Young's reaction tube, The oxygen reaction was carried out in the Young's reaction tube, and the reaction was carried out under oxygen conditions. The syringe was applied to the Young's reaction tubeAdd 0.04 mmol of co-catalyst I, 0.08 mmol of co-catalyst II, 0.2 mmol of aniline and 1 ml of absolute ethanol,The Young's reaction tube was placed on a magnetic stirrer and stirred at 150 ° C for 8 hours. After the reaction, the pH of the reaction solution was adjusted to neutral,The reaction solution was subjected to a post-treatment to obtain pure product of 2-methylquinoline in a yield of 93%.

References:

Suzhou Research Institute, Lanzhou Institute of Chemical Physics (LICP) of the Chinese Academy of Sciences (CAS);Jiang, Gaoxi;Li, Jixing;Yang, Huimeng;Xia, Chungu CN106543078, 2017, A Location in patent:Paragraph 0056; 0057

FullText