Pyridine, 2-(chloromethyl)-3-methyl- (7CI,8CI,9CI) synthesis
- Product Name:Pyridine, 2-(chloromethyl)-3-methyl- (7CI,8CI,9CI)
- CAS Number:4377-43-9
- Molecular formula:C7H8ClN
- Molecular Weight:141.6
63071-09-0
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4377-43-9
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$65.00/100mg
Yield:4377-43-9 94.9%
Reaction Conditions:
with dichloro sulfoxide in dichloromethane at 20; for 2 h;
Steps:
General Procedure for the synthesis of 10a-10c.
General procedure: To a solution of commercial 9a or 9b or 9c (3.56 mmol) in dichloromethane (20 mL) was added SOCl2 (2.8 mL). After 2 h stirring at room temperature, the reaction mixture was quenched with 2 M NaOH solution to pH 7-8. The solution was extracted several times with DCM, and the combined organic layers were washed saturated salt solution, dried over anhydrous MgSO4 and then evaporated in vacuo.
References:
Chen, Wei-Lin;Chen, Xin;Guo, Xiao-Ke;Jiang, Zheng-Yu;Li, Dong-Dong;Wang, Ying-Zhe;Xu, Jun-Jie;You, Qi-Dong [European Journal of Medicinal Chemistry,2020,vol. 188] Location in patent:supporting information
583-61-9
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87-90-1
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55-21-0
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4377-43-9
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$65.00/100mg
22710-07-2
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$16.00/1g
76-02-8
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4377-43-9
53 suppliers
$65.00/100mg
22710-07-2
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4377-43-9
53 suppliers
$65.00/100mg
52814-41-2
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4377-43-9
53 suppliers
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