PYRIDINE-2,3,6-TRIAMINE synthesis

5synthesis methods

Product Name:PYRIDINE-2,3,6-TRIAMINE
CAS Number:4318-79-0
Molecular formula:C5H8N4
Molecular Weight:124.14

3346-63-2
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4318-79-0
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Yield:4318-79-0 78%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol at 20; for 2 h;

Steps:

1.3 Step 3: Synthesis of pyridine-2, 3, 6-triamine (5)

To a solution of 4 (1.6 g, 10.38 mmol) in methanol (20 mL) was added 10% Pd/C (160 mg) and the resulting reaction mixture was stirred under hydrogen atmosphere at room temperature for 2 hours. After completion of reaction, the reaction mixture was filtered over a pad of cealite and washed with methanol. Filtrate was evaporated under reduced pressure to give the desired product 5 (1 g, 78%) as a purple color solid that was pure enough to take ahead for next step

References:

WO2020/120576,2020,A1 Location in patent:Page/Page column 34-35