ChemicalBook CAS DataBase List Pyridazin-3-amine

Pyridazin-3-amine synthesis

5synthesis methods

Product Name:Pyridazin-3-amine
CAS Number:5469-70-5
Molecular formula:C4H5N3
Molecular Weight:95.1

5469-69-2 Synthesis

5469-69-2
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5469-70-5
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Yield:5469-70-5 100%

Reaction Conditions:

with sodium hydroxide;hydrogen;palladium 10% on activated carbon in tetrahydrofuran;water at 20; for 48 h;

Steps:

147.1
Example 147; 4-(3-Phenyl-1,2,4-thiadiazol-5-yl)-N-pyridazine-1-carboxamide; (1) Pyridazine-3-amine; A mixture of 6-chloropyridazine-3-amine (5.00 g, 38.6 mmol), tetrahydrofuran (240 ml), sodium hydroxide (8.00 g, 200 mmol), water (32 ml) and 10% palladium-carbon (500 mg) was stirred under a hydrogen atmosphere at room temperature for 2 days, insolubles were filtered off and the filtrate was concentrated. The residue was dissolved in methanol (100 ml), insolubles were filtered off and the filtrate was concentrated to obtain the desired product as a solid quantitatively. ¹H-NMR (DMSO-d₆) δ; 2.51 (2H, br s), 6.46 - 6.49 (1H, m), 6.93 - 6.97 (1H, m), 8.06 - 8.08 (1H, m).

References:

Takeda Pharmaceutical Company Limited EP1813606, 2007, A1 Location in patent:Page/Page column 82

FullText

1120-95-2 Synthesis