Pregna-3,5-dien-20-one,3-methoxy- (7CI,8CI,9CI) synthesis
- Product Name:Pregna-3,5-dien-20-one,3-methoxy- (7CI,8CI,9CI)
- CAS Number:903-03-7
- Molecular formula:C22H32O2
- Molecular Weight:328.4883
Yield:903-03-7 80 %
Reaction Conditions:
with Pyridine hydrobromide in ethanol;water at 3 - 20;
Steps:
1-2 Example 1-2
Add 50.0 g of progesterone and 500 mL of methanol into the reaction flask and stir at room temperature. Add 0.4 g of pyridinium hydrobromide, stir and cool down to 3°C, add 27.5 g of trimethyl orthoacetate dropwise, after the drop is complete, keep warm and stir to react, and TLC monitors that there is no raw material progesterone. Slowly pour the reaction solution into a beaker containing 5% potassium hydroxide solution (500mL), add 200mL of water to wash, filter with suction, and dry to obtain 40.0g of an off-white solid, which is intermediate 1-2, with a yield of 80.0% .
References:
CN115141243,2022,A Location in patent:Paragraph 0041-0043
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