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ChemicalBook CAS DataBase List PLERIXAFOR

110078-46-1

PLERIXAFOR synthesis

5synthesis methods

Product Name:PLERIXAFOR
CAS Number:110078-46-1
Molecular formula:C28H54N8
Molecular Weight:502.78

Plerixafor can be synthesized by several related procedures starting from tetraazacyclotetradecane, the macrocyclic tetraamine cyclam. The general synthetic strategy entails the masking of three of the four ring nitrogens, followed by alkylation with para-xylylene dibromide, and subsequent removal of the masking groups. In one approach, tetraazacyclotetradecane is protected as the phosphorotriamide derivative by reaction with tris (dimethylamino)phosphine followed by oxidation with carbon tetrachloride and sodium hydroxide. After condensation with xylylene dibromide, the dimeric bis-phosphoramide intermediate is hydrolyzed to plerixafor by treatment with dilute hydrochloric acid solution.

623-24-5 Synthesis

alpha,alpha'-Dibromo-p-xylene

623-24-5
316 suppliers
$6.00/1g

PLERIXAFOR

110078-46-1
269 suppliers
$19.00/5mg

-

1-(4,8-bis-(2,2,2-trifluoroacetyl)-11-{4-[4,8,11-tris-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-ylMethyl]-benzyl}-1,4,8,11-tetraazacyclotetradec-1-yl)-2,2,2-trifluoroethanone

406939-93-3
14 suppliers
$160.00/2.5mg

PLERIXAFOR

110078-46-1
269 suppliers
$19.00/5mg

592516-98-8

592516-98-8
1 suppliers
inquiry

PLERIXAFOR

110078-46-1
269 suppliers
$19.00/5mg

623-24-5 Synthesis

alpha,alpha'-Dibromo-p-xylene

623-24-5
316 suppliers
$6.00/1g

295-37-4 Synthesis

1,4,8,11-TETRAAZACYCLOTETRADECANE

295-37-4
308 suppliers
$18.00/250mg

PLERIXAFOR

110078-46-1
269 suppliers
$19.00/5mg

1,4,8,11-Tetraazacyclotetradecane-1,4,8-tricarboxylic acid, 11,11'-[1,4-phenylenebis(methylene)]bis-, hexakis(1,1-dimethylethyl) ester (9CI)

175854-48-5
1 suppliers
inquiry

PLERIXAFOR

110078-46-1
269 suppliers
$19.00/5mg

PLERIXAFOR Related Search:

Varenicline tartrate GSK-3BETA INHIBITOR XII Enzalutamide Gefitinib Nintedanib esylate Alectinib Hydrochloride 1,4,8,11-TETRAAZACYCLOTETRADECANE

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