ChemicalBook CAS DataBase List Phenol, 4-ethenyl-2,6-dimethoxy-

Phenol, 4-ethenyl-2,6-dimethoxy- synthesis

8synthesis methods

Product Name:Phenol, 4-ethenyl-2,6-dimethoxy-
CAS Number:28343-22-8
Molecular formula:C10H12O3
Molecular Weight:180.2

530-59-6 Synthesis

530-59-6
307 suppliers
$10.00/1g

28343-22-8
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$499.01/5MG

Yield:28343-22-8 94%

Reaction Conditions:

in N,N-dimethyl-formamide at 170; for 0.5 h;

Steps:

4 Embodiment 4: a kind of preparation method of 4-vinylphenol compound:

0.2 mmol of 3,5-dimethoxy-4-hydroxycinnamic acid and 1 mL of solvent DMF were added to the pressure-resistant reaction flask, and the reaction was heated and stirred in an oil bath at 170°C for 30 min; after the reaction, the reaction solution was extracted with ethyl acetate 3 times, followed by The organic layer was washed with water and saturated sodium chloride solution, and the washed organic layer was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure, and the residue was subjected to silica gel column chromatography (V petroleum ether/V ethyl acetate=5 : 1) separation and purification to obtain 4-vinylphenol compound I-4 with a yield of 94%.

References:

CN113880695,2022,A Location in patent:Paragraph 0032-0034; 0059-0060

141-82-2 Synthesis