Phenethyl chloride synthesis
- Product Name:Phenethyl chloride
- CAS Number:622-24-2
- Molecular formula:C8H9Cl
- Molecular Weight:140.61
532-27-4
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622-24-2
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Yield:622-24-2 85%
Reaction Conditions:
with titanium tetrachloride in 1,2-dichloro-ethane for 3 h;Reflux;
Steps:
Representative procedure (compound 2)
General procedure: A solution of 2-chloro-1-[4-(propan-2-yl)phenyl]ethanone (1 g, 5.1 mmol) in dichloroethane (DCE) (10 mL) was placed in a 50 mLthree-mouth round-bottomed flask equipped with a reflux condenser, a calcium chloride drying tube, a thermometer and a magnetic stirring bar. To the stirred reaction solution at room temperature, tickle (0.115 mL, 25%) followed by PMHS (0.7 g, 12.2 mmol) were added from a syringe. The reaction mixture was heated to reflux and progress of the reaction monitored by thin layer chromatography (tlc) and stopped after three hours. The gelatinous reaction mixture was taken up in hexane (15 mL) and filtered under a plug of celite. The filter cake was washed with hexane (50 mL) and the filtrate concentrated in vacuo.
References:
Jumbam, Ndze D.;Makaluza, Siyavuya;Masamba, Wayiza [Bulletin of the Chemical Society of Ethiopia,2018,vol. 32,# 1,p. 179 - 184]
60-12-8
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622-24-2
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100-41-4
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1074-11-9
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622-24-2
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672-65-1
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292638-84-7
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622-24-2
269 suppliers
$5.00/5g