Oxytocin synthesis
- Product Name:Oxytocin
- CAS Number:50-56-6
- Molecular formula:C43H66N12O12S2
- Molecular Weight:1007.19
151937-33-6
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50-56-6
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Yield:50-56-6 98.5%
Reaction Conditions:
Stage #1:
Stage #2: with isoascorbic acid in acetic acid;
Steps:
31
H-Cys(Acm)-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (SEQ. ID. NO. 15) crude peptide prepared as described in Example 30 was purified on preparative C18 RP-HPLC column. Fractions containing >95% pure product were combined and diluted to concentrations of about 1 g/L. An equimolar amount of iodine in acetic acid was added under vigorous mixing at room temperature, and the excess iodine was neutralized by a small amount of ascorbic acid. The resulting solution was loaded on a C18 RP-HPLC column and purified to obtain fractions containing oxytocin at a purity of >98.5%. The fractions were treated to replace the counterion, collected and lyophilized to obtain final dry peptide. Residual TFA <0.25%.
References:
US2006/148699,2006,A1 Location in patent:Page/Page column 11
17912-60-6
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50-56-6
485 suppliers
$23.69/250iu