Nalpha-FMOC-L-Glutamine synthesis
- Product Name:Nalpha-FMOC-L-Glutamine
- CAS Number:71989-20-3
- Molecular formula:C20H20N2O5
- Molecular Weight:368.38
56-85-9
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82911-69-1
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71989-20-3
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Yield:71989-20-3 84%
Reaction Conditions:
with sodium carbonate in tetrahydrofuran;water
Steps:
To a stirred solution of L-glutamine (1.75 g, 12 mmole) and sodium carbonate (1.27 g, 12 mmole) in 30 ml of water, was added a solution of Fmoc-OSu (3.0 g, 8.9 mmole) in 60 ml of THF. After stirring overnight the mixture was concentrated under reduced pressure to remove the THF. The residue was diluted with 100 ml of 1 N hydrochloric acid . The white solid was collected by filtration and recrystallized in DMF-0.1 N hydrochloric acid aqueous solution to afford a white powder (38, 2.76 g). Yield: 84%. 1H-NMR (90 MHz, DMSO-d6) ppm: 12.47 (1H, s), 7.89-7.20 (10 H, m), 6.68 (1H, s, br), 4.22-3.90 (4H, m), and 2.25-1.86 (4H, m).
References:
M. Martin, Lenore;Hu, Bi-Huang US2006/161007, 2006, A1 Location in patent:Page/Page column 12
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56-85-9
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71989-20-3
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71989-20-3
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