N-Phenylanthranilic acid synthesis
- Product Name:N-Phenylanthranilic acid
- CAS Number:91-40-7
- Molecular formula:C13H11NO2
- Molecular Weight:213.23
Yield:91-40-7 100%
Reaction Conditions:
with copper (I) iodide;potassium carbonate in lithium hydroxide monohydrate;N,N-dimethyl-formamide at 100; for 1 h;Microwave irradiation;
Steps:
SC-1-39 SC-1-39 Acid
SC-1-39 Acid [0023] A microwave reactor tube was charged with ortho-iodo benzoic acid (496 mg, 2 mmol), aniline (0.45 mL, 4 mmol), K2CO3 (832 mg, 6 mmol), CuI (400 mg, 2.08 mmol) and 10 mL DMF/H2O (9:1). The reaction was subjected to 300 Watt microwave irradiation with the internal temperature maintained at 100° C. for 1 h. After completion of the reaction was observed by TLC, 1 N HCl (9 mL) was added to the reaction mixture to obtain a final pH of 6.0. The solvent was then removed under reduced pressure and water chased with toluene. The crude compound was isolated on SiO2 using hexane/EA and recrystallised from toluene to give 267 mg (63%) of white solid; mp: 176.6-177.0°
References:
US2014/135519,2014,A1 Location in patent:Paragraph 0023
35708-19-1
40 suppliers
$334.62/5g
91-40-7
318 suppliers
$10.00/1g
