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ChemicalBook CAS DataBase List N-Boc-4-broMo-L-phenylalanine Methyl ester
266306-18-7

N-Boc-4-broMo-L-phenylalanine Methyl ester synthesis

6synthesis methods
-

Yield:266306-18-7 96%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 20; for 3 h;Inert atmosphere;

Steps:

5 (S)-Methyl 3-(4-bromophenyl)-2-(tert-butoxycarbonylamino)propanoate (1)

Methyl iodide (25 g, 0.177 ml) and potassium carbonate (60.2 g, 0.436 ml) were added to a solution of Boc-(S)-2-amino-3-(4-bromophenyl)propanoic acid (50 g, 0.145 moi) in DMF (500 mL) under argon and the reaction mixture was stirred for 3 h at room temperature. The mixture was diluted with water (500 mL) and then extracted with EtOAc (500 mL). The organic layer was washed with brine (300 mL), dried over anhydrous sodium sulfate and concentrated to afford compound 1 (50 g, 96% yield).

References:

WO2015/32942,2015,A1 Location in patent:Page/Page column 42