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ChemicalBook CAS DataBase List N-(2-HYDROXYETHYL)-2,2,2-TRIFLUOROACETAMIDE
6974-29-4

N-(2-HYDROXYETHYL)-2,2,2-TRIFLUOROACETAMIDE synthesis

9synthesis methods
-

Yield:-

Reaction Conditions:

at 0 - 20;

Steps:

1.1.d 2,2,2-trifluoro-N-(2-hydroxyethyl)acetamide (IX)
Ethanolamine (8.5 mL, 141 mmol) was cooled to 0° C. Trifluoro acetic acid (22.3 mL, 289 mmol) was added dropwise. The reaction mixture was allowed to warm up to room temperature. The product precipitates as a white solid

References:

IMEC VZW;UNIVERSITEIT HASSELT;Lutsen, Laurence;Vanderzande, Dirk US2020/152395, 2020, A1 Location in patent:Paragraph 0219; 0221

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