ChemicalBook CAS DataBase List METHYL OROTATE

METHYL OROTATE synthesis

5synthesis methods

Product Name:METHYL OROTATE
CAS Number:6153-44-2
Molecular formula:C6H6N2O4
Molecular Weight:170.12

67-56-1 Synthesis

67-56-1
758 suppliers
$7.29/5ml-f

65-86-1 Synthesis

65-86-1
416 suppliers
$5.00/100mg

6153-44-2
123 suppliers
$7.00/250mg

Yield: 92.9%

Reaction Conditions:

with thionyl chloride at 0 - 5; for 6 h;Reflux;

Steps:

9.1
In a 500 mL three-necked flask,Add orotic acid(15.6 g, 0.10 mol),Then 300 mL of anhydrous methanol was added,Stirring down to 0 ,Maintain the temperature 0 ~ 5 drop add thionyl chloride(10.9 mL, 0.15 mol),And the temperature was raised to reflux for 6 hours.Slightly cold,Vacuum drying solvent,Add 50 mL of anhydrous methanol to lift off.150 mL of methyl t-butyl ether was added,Stirred at room temperature for 1 hour,Filter,Methyl tert-butyl ether wash.dry,To obtain 15.8 g of compound 1,Yield 92.9%.

References:

Shandong Chuangxin Pharmaceutical Research And Development Co., Ltd.;Jiang Hong;Lv Chuantao;Ma Chonglei;Lin Hongjie;Hao Lianfeng;Liu Yongyong;Lu Jingjing CN106831607, 2017, A Location in patent:Paragraph 0047