Methyl diethylphosphonoacetate synthesis
- Product Name:Methyl diethylphosphonoacetate
- CAS Number:1067-74-9
- Molecular formula:C7H15O5P
- Molecular Weight:210.16
Yield:1067-74-9 98%
Reaction Conditions:
at 135; for 10 h;
Steps:
4.11. Preparation of (2E,4E)-5-phenylpenta-2,4-dienoic acid (21)
A mixture of methyl chloroacetate (4.8 g, 44 mmol) and triethylphosphite (7.3 g, 44 mmol) was heated at 135 °C for 10 h. The mixture was allowed to cool to room temperature to afford the desired product, methyl 2-(diethylphosphoryl)acetate, in 98% yield (6.2 g) as a mixture of rotamers.
References:
Aung, Hnin Thanda;Furukawa, Tadashi;Nikai, Toshiaki;Niwa, Masatake;Takaya, Yoshiaki [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 7,p. 2392 - 2396] Location in patent:experimental part
![Acetic acid, 2-[bis[(trimethylsilyl)oxy]phosphinyl]-, methyl ester](/CAS/20210111/GIF/67605-34-9.gif)
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