(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate synthesis
- Product Name:(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
- CAS Number:114676-69-6
- Molecular formula:C11H19NO5
- Molecular Weight:245.27
24424-99-5
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114676-59-4
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$6.00/250mg
114676-69-6
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$6.00/1g
Yield:114676-69-6 100%
Reaction Conditions:
with dmap;triethylamine in water;acetone;
Steps:
1.4.2
[0347] To a solution of (2R,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride (4.4 g, 24.67 mmol) in Acetone and water (3:2, 30 mL) were added Et3N (6.8 mL , 49.28 mmol), DMAP (150 mg, 1.2 mmol). Then (Boc)20 (8.0 mL, 34.54 mmol) was added slowly and the reaction was stirred overnight. All the acetone was removed and diluted with EtOAc and washed with 0.5 N HC1, water, brine, dried and concentrated to yield 6.0 g of (2R,4R)-1- tert-butyl 2-methyl 4-hydroxypyrrolidine-l,2-dicarboxylate (quantitative).
References:
WO2011/130383,2011,A1 Location in patent:Page/Page column 104
135042-12-5
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74-88-4
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114676-69-6
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$6.00/1g
24424-99-5
863 suppliers
$13.50/25G
2584-71-6
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$6.00/1g
114676-69-6
187 suppliers
$6.00/1g
24424-99-5
863 suppliers
$13.50/25G
114676-47-0
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$95.00/250mg
114676-69-6
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$6.00/1g
67-56-1
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135042-12-5
196 suppliers
$6.00/1g
114676-69-6
187 suppliers
$6.00/1g