Yield:447461-21-4 89%

Steps:

9 Synthesis of 2-carboxy-4-hydroxy-3,5-lutidine

EXAMPLE 9 Synthesis of 2-carboxy-4-hydroxy-3,5-lutidine Starting with 2-carboxy-4-chloro-3,5-lutidine, a sodium methoxide nucleophilic substitution reaction was conducted as described above for 24 hours. The aqueous layer was acidified to pH 2.5 with concentrated Hydrochloric acid. The precipitate was filtered and washed with water and dried under vacuum at 50? C. The 2-carboxy-4-hydroxy-3,5-lutidine product was obtained as a light brown solid in 89% yield.

References:

US6437139,2002,B1