ChemicalBook CAS DataBase List Methyl 4-chloro-4-oxobutanoate

Methyl 4-chloro-4-oxobutanoate synthesis

5synthesis methods

Product Name:Methyl 4-chloro-4-oxobutanoate
CAS Number:1490-25-1
Molecular formula:C5H7ClO3
Molecular Weight:150.56

79-37-8
474 suppliers
$17.67/10gm:

3878-55-5 Synthesis

3878-55-5
248 suppliers
$9.00/1g

1490-25-1
188 suppliers
$24.00/5G

Yield:1490-25-1 91.3%

Reaction Conditions:

with N,N-dimethyl-formamide in dichloromethane for 2 h;

Steps:

1 Example 1
Dissolve 2.0 g of monomethyl succinate and 15 ml of methylene chloride in a single-mouth bottle, add 3.9 g of oxalyl chloride dropwise, and add 1-2 drops of N,N-dimethylformamide dropwise with stirring.After reacting for 2 hours, the reaction liquid was concentrated under reduced pressure to give 2.1 g (yield: 91.3%).Succinic acid monomethyl ester chloride.

References:

Wante Pharmaceutical (Hainan) Co., Ltd.;Chen Mengnan;Zhao Guolei;Li Enmin CN109553549, 2019, A Location in patent:Paragraph 0009

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3878-55-5 Synthesis

3878-55-5
248 suppliers
$9.00/1g

1490-25-1
188 suppliers
$24.00/5G

References