Methyl 3-amino-4-hydroxybenzoate synthesis
- Product Name:Methyl 3-amino-4-hydroxybenzoate
- CAS Number:536-25-4
- Molecular formula:C8H9NO3
- Molecular Weight:167.16
67-56-1
753 suppliers
$7.29/5ml-f
1571-72-8
260 suppliers
$8.00/1g
536-25-4
191 suppliers
$11.00/250mg
Yield:536-25-4 100%
Reaction Conditions:
with sulfuric acid for 24 h;Reflux;
Steps:
Step1: preparation of methyl 4-amino-3-nitrobenzoate (12).
General procedure: Toa solution of 4-amino-3-nitrobenzoic acid (11, 500 mg, 2.75 mmol) inMeOH (20 mL), a catalytic amount of concentrated sulfuric acid was added in a dropwisefashion. The mixture was heated at reflux temperature overnight. After beingcooled, the reaction was quenched by saturated NaHCO3solution andextracted by ethyl acetate.The organic layer was separated and dried over anhydroussodium sulfate. Filtration and concentrationin vacuogave 12 (519 mg, 97%); yellow solid
References:
Jaikhan, Pattaporn;Buranrat, Benjaporn;Itoh, Yukihiro;Chotitumnavee, Jiranan;Kurohara, Takashi;Suzuki, Takayoshi [Bioorganic and Medicinal Chemistry Letters,2019,vol. 29,# 10,p. 1173 - 1176] Location in patent:supporting information
99-42-3
187 suppliers
$8.00/5g
536-25-4
191 suppliers
$11.00/250mg
67-56-1
753 suppliers
$7.29/5ml-f
616-82-0
225 suppliers
$10.00/5g
536-25-4
191 suppliers
$11.00/250mg
75-36-5
580 suppliers
$17.92/100G
1571-72-8
260 suppliers
$8.00/1g
536-25-4
191 suppliers
$11.00/250mg
18107-18-1
211 suppliers
$33.00/5g
1571-72-8
260 suppliers
$8.00/1g
536-25-4
191 suppliers
$11.00/250mg