Methyl 3-amino-2-thiophenecarboxylate synthesis
- Product Name:Methyl 3-amino-2-thiophenecarboxylate
- CAS Number:22288-78-4
- Molecular formula:C6H7NO2S
- Molecular Weight:157.19
2365-48-2
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$14.00/25g
920-37-6
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$10.60/1gm:
22288-78-4
401 suppliers
$11.00/5g
Yield:22288-78-4 57%
Reaction Conditions:
with sodium methoxide in methanol at 0 - 20; for 1 h;
Steps:
1 Example 1 Synthesis of methyl 3-aminothiophene-2-carboxylate 1
Methyl thioglycolate (10.6 g, 100 mmol) and NaOMe (10.8 g, 200 mmol) were dissolved in MeOH (90 mL) followed by 2-chloroacrylonitrile (8.75 g, 100 mmol) in MeOH (10 mL) and added at 0 It was added dropwise to a round-bottomed flask at and stirred at room temperature for 1 h. After monitoring the reaction by TLC, the reaction mixture was concentrated under reduced pressure, added H2O (50 mL), extracted with EtOAc (4×50 mL), the organic phase was dried with MgSO4, filtered and concentrated under reduced pressure, and the corresponding product 1 (8.95 g) was obtained by silica gel column separation. ), white solid, melting point: 42°C, yield: 57%.
References:
CN114213400,2022,A Location in patent:Paragraph 0043-0047
79128-68-0
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852330-31-5
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$375.72/1g
22288-78-4
401 suppliers
$11.00/5g
67-56-1
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$9.00/25ml
55341-87-2
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$90.00/500mg
22288-78-4
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$11.00/5g
2689-69-2
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$53.39/250mg
22288-78-4
401 suppliers
$11.00/5g
