Maleimido-Tri(Ethylene Glycol)-Propionic Acid synthesis
- Product Name:Maleimido-Tri(Ethylene Glycol)-Propionic Acid
- CAS Number:518044-40-1
- Molecular formula:C13H19NO7
- Molecular Weight:301.29
55750-48-6
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$10.00/250mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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518044-40-1
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$293.32/0.5g
Yield: 75%
Reaction Conditions:
with sodium hydrogencarbonate at 0 - 20; for 1.66667 h;
Steps:
3-(2-{2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethoxy)propanoic acid
186 mg (555 μmol) of 3-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}propanoic acid trifluoroacetate were dissolved in 2.6 ml of saturated sodium hydrogencarbonate solution and admixed at 0° C. with 86 mg (555 μmol) of N-methoxycarbonylmaleimide. The reaction mixture was stirred at 0° C. for 40 min and at RT for 1 h, then cooled again to 0° C., adjusted to pH 3 with sulphuric acid and extracted 3× with 25 ml of ethyl acetate. The combined organic phases were dried over magnesium sulphate and concentrated. [1548] 126 mg (75% of theory) of the title compound were obtained. [1549] LC-MS (Method 1): Rt=0.53 min; m/z=302 (M+H)+
References:
Lerchen, Hans-Georg;Hammer, Stefanie;Harrenga, Axel;Kopitz, Charlotte Christine;Nising, Carl Friedrich;Sommer, Anette;Stelte-Luowig, Beatrix;Mahlert, Christoph;Schuhmacher, Joachim;Golfier, Sven;Greven, Simone;Bruder, Sandra US2015/23989, 2015, A1 Location in patent:Paragraph 1547-1549
518044-35-4
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518044-40-1
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252881-74-6
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$21.00/100mg
518044-40-1
71 suppliers
$293.32/0.5g