ChemicalBook CAS DataBase List Maleimide-PEG4-NHS Ester

Maleimide-PEG4-NHS Ester synthesis

5synthesis methods

Product Name:Maleimide-PEG4-NHS Ester
CAS Number:756525-99-2
Molecular formula:C22H31N3O11
Molecular Weight:513.49

6066-82-6 Synthesis

6066-82-6
753 suppliers
$5.00/10g

1263045-16-4 Synthesis

1263045-16-4
83 suppliers
$25.00/25mg

756525-99-2
96 suppliers
$150.00/100 mg

Yield: 0.109 g

Reaction Conditions:

with 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

Steps:

Referring to the scheme of synthesis of Compound O, β-alanine was treated with maleic anhydride in DMF and the acid so obtained was reacted with N-hydroxysuccinimide (NHS) under DCC coupling to give NHS-ester. The BOC protective group in commercially available t-blc-N-amido-dPEG4-acid was removed by treatment with TFA to give the TFA salt of the amine, which was reacted with previously synthesized NHS ester. The carboxylic acid so obtained was isolated and was coupled with N-hydroxysuccinimide using EDCI to furnish NHS ester Compound O.

References:

BIOLLIANCE C.V.;ABGENOMICS INTERNATIONAL INC.;LIN, Rong-hwa;LIN, Shih-yao;HSIEH, Yu-chi;HUANG, Chiu-chen WO2014/100762, 2014, A1 Location in patent:Paragraph 240; 248