Luminol synthesis

7synthesis methods

Product Name:Luminol
CAS Number:521-31-3
Molecular formula:C8H7N3O2
Molecular Weight:177.16

The synthesis of Luminol is as follows: To a reaction tube, add 140 mg of 3-nitrophthalhydrazide and 1.0 mL of 3 M sodium hydroxide solution. Stir with a rod, and to the resulting deep brown-red solution add 0.6 g of sodium hydrosulfite dihydrate (Na2S2O4 · 2 H2O, MW 210.2). Wash down the sides of the tube with a small amount of water. Heat to a gentle boil and keep the tube hot for 5 minutes. During this time some product may begin to crystallize. Add 0.4 mL of acetic acid, cool the tube in cold water, and stir. Collect the light-yellow product Luminol by suction filtration.
synthesis of Luminol

3682-15-3 Synthesis

3682-15-3
150 suppliers
$74.00/5g

521-31-3
524 suppliers
$5.00/100mg

Yield:521-31-3 83%

Reaction Conditions:

with formic acid;10% Pd/C;hydrogen at 35; for 5 h;Reagent/catalyst;

Steps:

3.3

To a three-necked flask was added 5 gl0 wt% palladium content meter) palladium on carbon, Stir evenly after heating to 35 ° C, A solution of 260 g of 85 wt% aqueous solution of formic acid was slowly added dropwise with stirring, The dropping time was 2 hours, and after the dropwise addition, Continue to react for 3 hours, the point plate to confirm 3-nitro phthalic acid hydrazide has been completely consumed, The pH was adjusted to 3-4 with 35 wt% concentrated hydrochloric acid and heated to 100 ° C, Hot filter, the filtrate cooled to l ° C, a large number of precipitation, Precipitate out completely after filtration, the filtrate for organic solvent recovery, The filter cake was washed with 300 ml of deionized water and dried to give 182 g of luminol (3-aminophthalohydrazide).

References:

CN106810501,2017,A Location in patent:Paragraph 0062