Loxoprofen sodium synthesis
- Product Name:Loxoprofen sodium
- CAS Number:80382-23-6
- Molecular formula:C15H19NaO3
- Molecular Weight:270.3
81762-92-7
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80382-23-6
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Yield:80382-23-6 35.36 g
Reaction Conditions:
with sodium hydroxide in ethanol; for 1 h;Reflux;
Steps:
16 Preparation of loxoprofen sodium
Methyl 2-(4-((2-oxocyclopentyl)methyl)phenyl) propionate (compound 6, 38 g, 154.28 mmol) was introduced into a 500 ml three-necked flask, ethanol (200 ml) was added, refluxed, and sodium hydroxide solution (20.9 g, 30% by mass) was dropped to the resulting mixture for 1 hour. After completion of dripping, the material was concentrated to dryness. The residue was recrystallized from ethanol-methyl tert-butyl ether to give a white powdery solid (35.36 g, 131.80 mmol). Molar yield 85.43%, HPLC purity 99.7%
References:
CN106699559,2017,A Location in patent:Paragraph 0116-0118
99807-54-2
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111128-12-2
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2362-36-9
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80382-23-6
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$6.00/250mg