ChemicalBook CAS DataBase List Losartan potassium

Losartan potassium synthesis

5synthesis methods

Product Name:Losartan potassium
CAS Number:124750-99-8
Molecular formula:C22H23ClKN6O
Molecular Weight:462.01

114798-26-4
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$6.00/250mg

124750-99-8
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$5.00/1g

Yield:124750-99-8 90%

Reaction Conditions:

with potassium hydroxide in methanol;isopropyl alcohol at 20; for 0.5 h;

Steps:

16
85 g of losartan was suspended in isopropanol (250 ml), and a solution prepared by dissolving 12.1 g of potassium hydroxide in methanol (85 ml) was slowly added thereto, followed by stirring for 30 minutes at room temperature. The resulting solution was filtered to remove insoluble materials and the filtrate was refluxed while adding cyclohexane (1,000 ml) thereto. Then, the resulting mixture was distilled to remove 340 ml of solvent and the residue containing solids was slowly cooled to room temperature. After stirring for 4 hours, the solid material was filtered, washed with a mixture of isopropanol and cyclohexane, and dried at 45 °C, to obtain 87.3 g of the title compound (yield: 90 %).[68][69] Melting point: 269°C to 274°C[70] ¹H-NMR (DMSO-d₆, ppm): 7.65 (IH, m), 7.4 (2H, m), 7.3 (IH, m), 7.15 (2H, d),6.95 (2H, d), 5.45 (IH, br), 5.3 (2H, s), 4.4 (2H, s), 2.54 (2H, m), 1.55 (2H, m), 1.31 (2H, m), 0.9 (3H, t).

References:

HANMI PHARM. CO., LTD. WO2007/133040, 2007, A1 Location in patent:Page/Page column 7; 8

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124750-67-0 Synthesis