Levamisole hydrochloride synthesis
- Product Name:Levamisole hydrochloride
- CAS Number:16595-80-5
- Molecular formula:C11H13ClN2S
- Molecular Weight:240.75
Dibenzoyl-D-tartaric acid is boiled in water for 40min, hydrolyzed and neutralized with sodium hydroxide solution to pH 7.5, and then added to racemic tetraimidazole. The levamisole is precipitated by generating salt with bisbenzoyl-tartaric acid. After separation, add sodium hydroxide solution to PH=9 and decompose levamisole. Then dissolved in dilute hydrochloric acid solution, after decolorization by activated carbon, the filtrate was concentrated nearly dry, and crystallized by adding acetone and cooling to 0℃. Filtered and dried to obtain levamisole hydrochloride.
14769-73-4
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16595-80-5
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Yield:16595-80-5 94%
Reaction Conditions:
with hydrogenchloride in acetonitrile at 40 - 50; for 1 h;
Steps:
3. In the reaction flask, add 10.0 g of compound (V),50g acetonitrile,5.3g hydrochloric acid,The temperature was raised to 40-50°C for 1 h, then cooled to 0-10°C,filter,11.1 g of white solid compound (VI) was obtained in a yield of 94%.
References:
CN114315753,2022,A Location in patent:Paragraph 0053-0054; 0058
![(R)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole monohydrochloride](/CAS/GIF/16595-76-9.gif)
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